Baclofen: Beneficial To Alcohol Dependent Patients

Baclofen is a gamma-aminobutyric acid (GABA) receptor agonist, specifically for the GABA receptors. The generic drug is a centrally acting skeletal muscle relaxant. It’s main use is as an antispastic agent, treating symptoms caused by multiple sclerosis, including spasm, pain, and stiffness. The cost of prescription medication for multiple sclerosis is soaring, leaving sufferers and caregivers worried about finances. InternationalDrugMart.com understands the stress of this debilitating condition, which is why customers prefer to buy baclofen generic from International Drug Mart.com. The bio-equivalent generic is much cheaper than the branded prescription drug, Lioresal.

Doctors may also prescribe the drug for treating trigeminal neuralgia, tardive dyskinesia and intractable hiccups. The drug is prescribed for long periods, sometimes years, as it retains its therapeutic anti-spasmodic effects, i. e., the body doesn’t develop tolerance towards the drug. However, studies show that some patients receiving intrathecal baclofen treatment, i. e., injecting drugs directly into the spinal canal, may develop tolerance towards the drug.

Treating Alcohol Withdrawal Syndrome is also among the newer Baclofen uses that show promising results. At low baclofen dose, it acts as an anti-craving agent with little risk of physical dependency. Giovanni Addolorato, MD, Institute of Internal Medicine, Italy, says, “Our results suggest that baclofen, because of its anti –craving action and safety, could have an important role for treatment of alcohol-dependent patients with advanced liver disease.”

The Baclofen for the Treatment of Alcohol Dependence (BACLAD) study demonstrated that many more patients randomly assigned to receive Baclofen abstained during the 12 -week high-dose phase of the study than patients who received placebo.

The drug is also judged to be safe to prescribe patients with liver disease as Baclofen is mainly metabolized through the kidneys, unlike other alcohol dependency drugs that are metabolized in the liver and are contraindicated for patients with cirrhosis.

While the drug does not seem to exhibit hallucinogenic properties, Baclofen’s side effects include drowsiness, dizziness, headache, seizures, nausea, low blood pressure, constipation, confusion, insomnia, and increased urinary frequency or urinary retention. Don’t discontinue Baclofen abruptly as this causes seizures, high fever, rebound spasticity, muscle rigidity and other life threatening symptoms. Patients are ‘weaned’ away, with Baclofen dosage being gradually reduced, under the prescribing physician’s orders.

Though branded drugs are expensive, they are beyond the reach of many who don’t have medical insurance. Buying generic Baclofen enables multiple sclerosis patients and people with spinal cord injuries to achieve normalcy without facing financial ruin.

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